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AGTC Announces Topline Interim Six-Month Data of XLRS Gene Therapy from Ongoing Phase 1/2 Clinical Trial

Applied Genetic Technologies Corporation (AGTC) , a leading developer of gene therapies, has reported the six-month follow-up data in all patients treated with its gene therapy for X-linked retinoschisis (XLRS) in its Phase 1/2 clinical trial. The company reported that no consistently significant clinical activity from the treatment was observed after six months. AGTC will continue to analyze all of the XLRS trial data and complete all visits specified in the clinical protocol. However, if the data at additional follow-up data visits are consistent with the current six-month findings, the company has stated that they will not further develop the product. A total of 27 subjects were treated, and all completed study visits through at least six months. Thirteen adult participants received the high dose of the treatment. The study subjects also included five pediatric patients who received the medium dose, and nine adults who received medium and low doses of the gene therapy. All partici...
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What to Know About Resveratrol

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The number of nutrients in the world are nearly infinite. It seems like every other day, researchers discover another vitamin, mineral, antioxidant, chemical, etc. with possible benefits and side effects. One of the newer discoveries in our lifetimes is resveratrol, and its effects are still being researched. What Is Resveratrol? Resveratrol is part of a group of compounds called stilbenes, which are polyphenols. These stilbenes act like antioxidants. Found in plants as part of the defense system, resveratrol protects against diseases and helping the plant survive a lack of nutrients. Resveratrol, like grape seed extract , is found in red and purple grapes and red wine, as well as peanuts, berries like mulberries, blueberries, and cranberries, and the Japanese knotweed plant. However, unlike grape seed extract, resveratrol itself contains potent antioxidant abilities. Vitamin and supplement manufacturers extract most of their resveratrol from grape skins, but researchers consider r...
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The Hidden Perils of Eye Rubbing

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Written by Dr. David Evans Last modified on December 14, 2018 How often do you rub your eyes? It’s a perfectly natural thing that we all find ourselves doing from time to time. Whether you’re tired from an early morning rise, have an itch you need to scratch or are experiencing fatigue related to digital eye strain, rubbing your eyes can often provide the short-term relief you crave. But at what cost? Generally speaking, eye rubbing isn’t always a negative. Rubbing the eyes can stimulate tear production which can lubricate and offer relief for dry, itchy eyes. The pressure that rubbing puts on the eyes can also stimulate the vagus nerve, which lowers your heartrate and helps to relieve stress. Thus the satisfied feeling from rubbing your eyes. However, if you make it a frequent habit, or are a little over-aggressive with the pressure against the eye, you could cause permanent damage to your eyes. Superficial Damage Dark circles around your eyes or constant bloodshot eyes are somet...
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