Wide-field OCT protocols offer better sensitivity for detecting HCQ retinopathy among Asians

wide-field-oct-protocols-offer-better-sensitivity-for-detecting-hcq-retinopathy-among-asians.jpg

JAN 16, 2018

Retina/Vitreous


Investigators have found that standard OCT protocols may be inadequate for detecting hydroxychloroquine (HCQ) retinopathy in some Asian patients.

Study design

This was a prospective study on 48 eyes of 24 Asian patients with HCQ retinopathy. Participants underwent imaging with spectral domain OCT (6 mm line and 6×6-mm2 volume scans) and swept-source OCT (9-mm line scans, 6×6-mm2 and 12x9-mm2 volume scans).

Outcomes

Approximately one-third of eyes had photoreceptor defects that were greater than 3 mm away from the fovea. These peripheral lesions were not covered by standard OCT scans, and were seen only on wide-field line or volume scans.

The 9-mm line scans showed significantly better sensitivity than 6-mm scans in detecting HCQ retinopathy (P<0.001). Wide volume scan also showed greater sensitivity over standard volume scans (P=0.001).

Limitations

This study was limited by a relatively small sample size with varying degrees of retinopathy severity. The cohort included only Korean patients and it is possible that distribution of HCQ retinopathy is different between Koreans and other Asian patients.

Clinical significance

This study showed a pericentral distribution of retinopathy among patients of Korean descent. These may be missed by standard OCT protocols using 6-mm line scans or 6×6-mm volume scans. As such, the authors recommend wide-field OCT protocols for screening in Asian patients taking HCQ.

View Abstract American Journal of Ophthalmology, December 2017

https://www.aao.org/editors-choice/wide-field-oct-protocols-offer-better-sensitivity-

Comments

Post a Comment

Popular posts from this blog

Week in review: Pay raise, Von’s Vision, gonio-<em>what?</em>

Image
APR 13, 2018 By Anni Griswold Comprehensive Ophthalmology, Cornea/External Disease, Glaucoma, Pediatric Ophth/Strabismus Above: The GonioPEN (Credit: Nanyang Technological University) A weekly roundup of ophthalmic news from around the web. Ophthalmologists earn more than the average physician , and their salaries are on the rise (+3% over the last year, to be precise). Eye docs will earn a mean $375,000 this year—more than the physician average of $299,000, but well below a typical plastic surgeon’s paycheck. See for yourself in Medscape’s 2018 Physician Compensation Report . Medscape A special supplement to USA Today will highlight the work of Von Miller , a 28-year-old linebacker for the Denver Broncos and former Super Bowl MVP. Through his foundation, Von’s Vision, Miller connects thousands of underprivileged children in Denver with affordable, high-quality eye care. His interview will appear in the “Vision Health” campaign during World Glaucoma Week, available in pr...
Read more

Patch with Microneedles Could Replace Eye Injections

Image
Instead of getting eye injections, patients with serious eye diseases may be eligible for a contact lens-type patch. 1 Injections are often recommended for eye diseases such as Wet (advanced) Age-Related Macular Degeneration, macular edema, and glaucoma. The new patch is inserted painlessly like a contact lens. It delivers tiny microneedles containing medication. The microneedles are made from natural materials and dissolve over time, gradually releasing medicine. Patients would be more likely to stick with a regimen that does not involve eye injections. Eye Injections: Stick a Needle in My Eye Patients generally dread eye injections. Injections must be performed in a doctor’s office. Eye injections can be painful, and they are inconvenient. They can introduce infection. And they can damage the eye. Avastin, Eylea, and Lucentis are injectable medications that discourage new blood vessel growth. These anti-VEGF medicines are useful for advanced Macular Degeneration , Diabetic Retino...
Read more

Incidence of eyelid SCC appears to be rising

FEB 12, 2018 Oculoplastics/Orbit This retrospective study examined demographic risk factors for developing eyelid squamous cell carcinoma (SCC). Study design Using data from the National Cancer Registration and Analysis Service, investigators identified all cases of eyelid SCC in England between 2000 and 2014. Outcomes Over the 15-year study period, there were 4,022 patients with newly diagnosed SCC affecting the eyelid. The age-standardized number of reported cases of eyelid SCC rose approximately 2% per year over the study period. The risk for developing an eyelid SCC approximately doubled each decade after age 60. Men were at 1.9-times greater relative risk compared with women. The authors did not find any association between income quintile and risk of SCC. Limitations The cause for the increasing incidence of eyelid SCC was not studied. While age may represent one factor, others such as an increasing rate of patients receiving immunosuppression therapies may als...
Read more