Retinitis Pigmentosa Gene-Editing Studied on Human Embryos

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The genetic eye disease Retinitis Pigmentosa is the target of gene-editing research on human embryos by Dr. Dietrich Elgi at Columbia University. National Public Radio reported on this research1 shortly after a Chinese scientist announced he had created the world’s first two gene-edited babies.2 Both scientists use the CRISPR tool to genetically modify human embryos. However, the experiments at Columbia are for research purposes only. These embryos are destroyed within one day for study.   Creating genetically modified human babies is illegal worldwide. The edited genes will be passed down to future generations. Genetic modifications could have dangerous or even lethal side effects. Also, “designer babies” would start a competition to build ideal humans, modified for non-medical reasons such as strength or intelligence. Scientific research is subject to ethics oversight. The Chinese genetic researcher, He Jiankui, acted independently and without approval. He believed that engineering resistance to Human Immunodeficiency Virus (HIV) outweighed any ethical concerns. The scientific community disagreed. He was put on unpaid leave by the Southern University of Science and Technology in Shenzhen. A local medical ethics board is investigating. Retinitis pigmentosa is relatively rare, affecting 1 in 3,700 people. The cause is one of a host of over 100 different genetic mutations. The problem may lie with the genes that affect rod and cone photoreceptors (particularly the rods essential for side and night vision), retinal pigment epithelium mutations, or abnormalities in the retina. Symptoms include gradual vision loss, poor adaptation to light changes, difficulty seeing at night, limited peripheral vision, and certain types of color blindness. People who have a mutated gene for retinitis pigmentosa would welcome giving birth to children who are neither afflicted nor carriers. Treatment options for this eye disease are limited. (Editor’s Note: Please see our page on natural support for Retinitis Pigmentosa) Dr. Elgi’s research at Columbia is carefully approved and monitored by a panel of bioethicists and other scientists. In the future, he plans to allow the embryos to develop further. However, the embryos are not intended for implantation. They are not meant to develop into a full-term baby. Genetic research is underway for several other clearly genetic eye diseases, including Fuch’s Corneal Dystrophy, Leber’s Hereditary Optic Neuropathy, and Leber Congenital Amaurosis. The majority of eye diseases, such as cataracts, macular degeneration, and glaucoma, are influenced more by lifestyle than any genetic predisposition.

https://www.lvcenter4sight.com/retinitis-pigmentosa-gene-editing-studied-on-human-embryos/

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