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FDA Authorizes Clinical Trial for CRISPR/Cas9 Therapy for LCA 10

Editas Medicine , a company developing gene-editing treatments, has received authorization from the US Food and Drug Administration to launch a clinical trial for its emerging CRISPR/Cas9 therapy for people with a mutation in the gene CEP290, which causes Leber congenital amaurosis 10 (LCA10). LCA causes severe vision loss or blindness at birth. Known as EDIT-101, the treatment will be evaluated in a Phase 1/2, dose-escalation clinical trial.  The company expects to enroll 10 to 20 patients. Further details and contact information for the study will be listed soon at www.clinicaltrials.gov . EDIT-101 targets a specific mutation, “c.2991+1655A>G” in intron 26, of the CEP290 gene. Editas has earned a $25 million milestone payment from Allergan as part of a drug-development alliance. “We are very pleased with this historic milestone in the treatment of inherited retinal diseases,” says Stephen Rose, PhD, chief scientific officer, Foundation Fighting Blindness. “EDIT-101 is the fi...
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Glaucoma Study Finds Lower Intra-ocular Pressure from Mindfulness Meditation

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According to a small study published in the Journal of Glaucoma , a short course of mindfulness meditation reduced intraocular pressure (IOP) in patients with primary open angle glaucoma (POAG). The practice also normalized stress biomarkers and positively modified gene expression. Mindfulness meditation may be a therapeutic resource to reduce IOP and help glaucoma patients. Glaucoma is the second-leading cause of blindness in the U.S. This serious eye disease affects mostly seniors. They gradually develop “tunnel vision” due to optic nerve damage . Any lost sight cannot be restored. For that reason, early detection and intervention are necessary. Primary open angle glaucoma is the most common form of glaucoma. People who are developing glaucoma often do not notice until vision is threatened. Regular eye exams are important for catching glaucoma. Most of the time, intra-ocular pressure is high in open-angle glaucoma patients. The doctor and patient will aim to keep intra-ocular pres...
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The Effects of Screen Time for Kids

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As the holidays approach, there are many digital gadgets children may be asking for or receiving. Some of the more popular gifts include flat-screen TVs, tablets, phones, streaming devices (Firestick, Roku, Apple TV, etc.), and gaming systems. Even Fisher-Price is offering the Think & Learn Smart Cycle, which syncs with a tablet for kids to play learning games while they ride the attached stationary bike. While some of these devices add learning opportunities, most of them come with added screen time, which may be cause for concern. The effects of excessive screen time are usually considered when adults work on computers for 8+ hours a day , but parents are starting to notice their children’s symptoms. Device Use & Symptoms in Young People In a survey of 300 US parents, half of the participants reported that their children spend too much time on devices. However, over two-thirds believe device usage won’t change and say they won’t be cutting back any time soon. Because of thi...
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